منابع مشابه
Vascular endothelial growth factors and vascular permeability
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-mediated permeability differs in its time course, but has common involvement of m...
متن کاملVascular growth factors and lymphangiogenesis.
Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered already 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until recently. This is in ...
متن کاملrole of vascular endothelial growth factors in ocular neovascular diseases
the most important progress in the field of retinal diseases during recent years might be the introduction of pharmacotherapy. age-related macular degeneration for instance was an irreversible disease leading to permanent anatomical and functional changes in the macula up to the previous decade; however, the use of anti-vascular endothelial growth factor agents (anti-vegfs) not only stops the p...
متن کاملVascular endothelial growth factors and angiogenesis.
VEGF was discovered in 1989. Research -conducted over the past 10 years has -demonstrated that VEGF is a major regulator of angiogenesis and vasculogenesis. This paper reviews the molecular data on the multiple forms of VEGF, their signalling and accessory receptors. Five genes encoding VEGF-like proteins have been identified; the different isoforms of each VEGF molecule are generated by altern...
متن کاملGene therapy with vascular endothelial growth factors.
Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance during embryogenesis and in adults. The present review summarizes the current status of therapeutic angiogenesis using VE...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2013
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-013-1281-9